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Abstract Detail



anti-inflammatory activity of four leaves extracts in lipopolysaccharide-stimulated raw264.7 macrophages.

Jitpisute Chunthorng-Orn, Bhanuz Dechayont, Pathompong Phuaklee and Arunporn Itharat
The leaves of Crinum asiaticum (CM), Ricinus communis (RC), Alpinia galangal (AG) and Morinda citrifolia (MC) are commonly used to relieve swelling and aching pain of the muscles in Thai traditional medicine. Thus, the objective of this study is to investigate the effect of the four leaves extracts on the production of pro-inflammatory cytokines by macrophage. Fresh plant materials were extracted by maceration in 95% ethanol and boiling in water. For anti-inflammation activity, these extracts were tested for suppression of nitric oxide (NO) production in LPS-induced RAW264.7 cells. The ethanolic extract of Crinum asiaticum leaves exhibited the highest anti-inflammatory potential (IC50 value ± SEM was 1.88 ± 0.21 µg/mL), whereas the aqueous extract of Ricinus communis leaves showed IC50 value ± SEM = 16.197 ± 1.61 µg/mL. In contrast, the ethanolic extracts of Ricinus communis, Alpinia galangal, Morinda citrifolia and the aqueous extracts of Crinum asiaticum, Alpinia galangal and Morinda citrifolia showed no inhibitory activity on nitric oxide (NO) release (IC50 > 100 μg/mL). These results support using Crinum asiaticum and Ricinus communis leaves to treat muscle inflammation, but these extracts should be further investigated another anti-inflammation method. Keywords: Anti-inflammation, Nitric oxide, Crinum asiaticum, Ricinus communis, Alpinia galangal, Morinda citrifolia

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1 - Thammasat University, Applied Thai Traditional Medicine, Faculty of medicine, 99/209 Moo 18 Paholyotin Road, KlongNeung, KlongLuang, Pathumthani, 12120, Thailand


Presentation Type: Poster
Session: P, Ethnobotany Posters
Location: Arizona Ballroom/Starr Pass
Date: Monday, July 29th, 2019
Time: 5:30 PM This poster will be presented at 6:15 pm. The Poster Session runs from 5:30 pm to 7:00 pm. Posters with odd poster numbers are presented at 5:30 pm, and posters with even poster numbers are presented at 6:15 pm.
Number: PET002
Abstract ID:189
Candidate for Awards:None

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